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COX-2 inhibitors are less likely than nonselective NSAIDs, like Advil® (ibuprofen) or Motrin IB® (ibuprofen), to cause ulcers in the stomach or intestine. However, all NSAIDs, including COX-2 inhibitors, can cause serious side effects, such as bleeding and ulcers in the stomach or intestine at any time. COX-2 inhibitors also may cause allergic reactions. Other potential side effects include fluid retention, high blood pressure, or kidney problems. The American College of Rheumatology guidelines recommend that all patients who take COX-2 inhibitors have a complete blood cell count yearly.
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